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吸附剂对百草枯胃肠道吸收的抑制作用。

Inhibition of the absorption of paraquat from the gastrointestinal tract by adsorbents.

作者信息

Clark D G

出版信息

Br J Ind Med. 1971 Apr;28(2):186-8. doi: 10.1136/oem.28.2.186.

DOI:10.1136/oem.28.2.186
PMID:5572687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009264/
Abstract

186-188. The efficacy of the oral administration of adsorbents Kaolin, Decalso, Amberlite, Bentonite and Fuller's Earth in preventing the toxic actions of ingested paraquat (1,1'-dimethyl-4,4'-dipyridylium) has been assessed using rats and cats. Only Bentonite and Fuller's Earth were found to have any effect, and they were both more effective than a simple stomach wash. It is suggested that these materials may be useful as immediate antidotes to paraquat poisoning in man. Fuller's Earth is preferable to Bentonite as it can be used as a more concentrated suspension, leading to a beneficial reduction in therapeutic volume.

摘要

186 - 188. 已使用大鼠和猫评估了口服吸附剂高岭土、Decalso、 Amberlite、膨润土和漂白土预防摄入百草枯(1,1'-二甲基-4,4'-联吡啶)毒性作用的效果。仅发现膨润土和漂白土有任何效果,且它们都比单纯洗胃更有效。建议这些物质可作为人类百草枯中毒的即时解毒剂。漂白土比膨润土更可取,因为它可以制成更浓缩的悬浮液,从而有益地减少治疗量。

相似文献

1
Inhibition of the absorption of paraquat from the gastrointestinal tract by adsorbents.吸附剂对百草枯胃肠道吸收的抑制作用。
Br J Ind Med. 1971 Apr;28(2):186-8. doi: 10.1136/oem.28.2.186.
2
Treatment of paraquat ingestion.百草枯摄入的治疗。
Br Med J. 1971 Sep 4;3(5774):580. doi: 10.1136/bmj.3.5774.580-a.
3
Treatment of paraquat poisoning in man: methods to prevent absorption.人类百草枯中毒的治疗:防止吸收的方法
Hum Toxicol. 1987 Jan;6(1):49-55. doi: 10.1177/096032718700600108.
4
Paraquat poisoning.百草枯中毒
Biomed Pharmacother. 1987;41(4):196-7.
5
Paraquat poisoning: manifestations and therapy.百草枯中毒:表现与治疗
Am J Med. 1975 Dec;59(6):751-3. doi: 10.1016/0002-9343(75)90459-3.
6
Activated charcoal is as effective as fuller's earth or bentonite in paraquat poisoning.在百草枯中毒方面,活性炭与漂白土或膨润土的效果相同。
Klin Wochenschr. 1982 Feb 15;60(4):207-10. doi: 10.1007/BF01715588.
7
The treatment of paraquat poisoning using oral sorbents and charcoal haemoperfusion.使用口服吸附剂和活性炭血液灌流治疗百草枯中毒。
Acta Pharmacol Toxicol (Copenh). 1977;41 Suppl 2:109-17.
8
Screening of various adsorbents for protection against paraquat poisoning.筛选各种吸附剂以预防百草枯中毒。
Bull Environ Contam Toxicol. 1973 Oct;10(4):193-9. doi: 10.1007/BF01684544.
9
[Paraquat poisoning].
Ugeskr Laeger. 1981 May 4;143(19):1202-6.
10
Successful treatment of paraquat poisoning: activated charcoal per os and "continuous hemoperfusion".百草枯中毒的成功治疗:口服活性炭和“持续血液灌流”
J Toxicol Clin Toxicol. 1982 Oct;19(8):807-19. doi: 10.3109/15563658208992514.

引用本文的文献

1
Evaluation of gastric lavage efficiency and utility using a rapid quantitative method in a swine paraquat poisoning model.在猪百草枯中毒模型中使用快速定量方法评估洗胃效率和效用。
World J Emerg Med. 2020;11(3):174-181. doi: 10.5847/wjem.j.1920-8642.2020.03.008.
2
Activated charcoal is as effective as fuller's earth or bentonite in paraquat poisoning.在百草枯中毒方面,活性炭与漂白土或膨润土的效果相同。
Klin Wochenschr. 1982 Feb 15;60(4):207-10. doi: 10.1007/BF01715588.
3
Tailor-made agarose-based reactive beads for hemoperfusion and plasma perfusion.用于血液灌流和血浆灌流的定制琼脂糖基反应性微珠。
Appl Biochem Biotechnol. 1984;10:167-82. doi: 10.1007/BF02783749.
4
Screening of various adsorbents for protection against paraquat poisoning.筛选各种吸附剂以预防百草枯中毒。
Bull Environ Contam Toxicol. 1973 Oct;10(4):193-9. doi: 10.1007/BF01684544.
5
Effective treatment for paraquat poisoning in rats and its relevance to treatment of paraquat poisoning in man.大鼠百草枯中毒的有效治疗及其与人类百草枯中毒治疗的相关性。
Br Med J. 1974 Dec 7;4(5944):569-71. doi: 10.1136/bmj.4.5944.569.
6
[Clinical treatment of paraguat-intoxication (author's transl)].百草枯中毒的临床治疗(作者译)
Pneumonologie. 1974;150(2-4):173-9. doi: 10.1007/BF02179316.
7
Kinetics of in vitro paraquat removal by cation-exchange resin.阳离子交换树脂体外去除百草枯的动力学
Bull Environ Contam Toxicol. 1988 Jul;41(1):12-6. doi: 10.1007/BF01689053.
8
In vitro adsorption removal of paraquat by activated carbon and cation exchange resin.活性炭和阳离子交换树脂对百草枯的体外吸附去除
Bull Environ Contam Toxicol. 1989 Jun;42(6):926-30. doi: 10.1007/BF01701637.
9
Paraquat ingestion and pulmonary injury.百草枯摄入与肺损伤。
West J Med. 1978 Jan;128(1):26-34.

本文引用的文献

1
Accidental poisoning by paraquat: Report of two cases in man.百草枯意外中毒:两例人体病例报告。
Br Med J. 1966 May 21;1(5498):1272-3. doi: 10.1136/bmj.1.5498.1272.
2
Absorption and excretion of diquat and paraquat in rats.大鼠体内敌草快和百草枯的吸收与排泄
Br J Ind Med. 1966 Apr;23(2):133-6. doi: 10.1136/oem.23.2.133.
3
The toxicity of paraquat.百草枯的毒性。
Br J Ind Med. 1966 Apr;23(2):126-32. doi: 10.1136/oem.23.2.126.
4
Inhibition of aspirin absorption by activated charcoal and apomorphine.活性炭和阿扑吗啡对阿司匹林吸收的抑制作用。
Clin Pharmacol Ther. 1969 Sep-Oct;10(5):710-3. doi: 10.1002/cpt1969105710.
5
Paraquat poisoning treated by forced diuresis.采用强制利尿法治疗百草枯中毒。
Br Med J. 1968 Aug 3;3(5613):290-1. doi: 10.1136/bmj.3.5613.290.
6
Acute renal failure in case of Paraquat poisoning.百草枯中毒所致急性肾衰竭
Br Med J. 1968 Mar 23;1(5594):749-50. doi: 10.1136/bmj.1.5594.749.