大鼠百草枯中毒的有效治疗及其与人类百草枯中毒治疗的相关性。
Effective treatment for paraquat poisoning in rats and its relevance to treatment of paraquat poisoning in man.
作者信息
Smith L L, Wright A, Wyatt I, Rose M S
出版信息
Br Med J. 1974 Dec 7;4(5944):569-71. doi: 10.1136/bmj.4.5944.569.
After oral administration of a lethal dose of paraquat to rats the plasma concentration remained relatively constant over four to 30 hours and was related to the paraquat content of the small intestine over the first 16 hours. During the first 30 hours the concentration of paraquat in the lung rose progressively above that of the plasma to levels which are known to cause pulmonary damage. A treatment has been devised which prevents the absorption of paraquat into the plasma and prevents accumulation of paraquat in the lung. This treatment consists of a stomach was followed by four administrations of bentonite plus purgatives at two- to three-hour intervals. Even when treatment was delayed until 10 hours after administration of paraquat 80% survival was obtained. The relevance of this treatment to paraquat poisoning in man is discussed in the light of the finding that slices of human lung accumulate paraquat in the same way as those of rat lung.
给大鼠口服致死剂量的百草枯后，血浆浓度在4至30小时内保持相对恒定，并且在最初16小时内与小肠中的百草枯含量相关。在最初30小时内，肺中百草枯的浓度逐渐升至高于血浆浓度的水平，已知该水平会导致肺损伤。已经设计出一种治疗方法，可防止百草枯吸收到血浆中，并防止百草枯在肺中蓄积。这种治疗方法包括洗胃，随后每隔两到三小时服用四次膨润土加泻药。即使将治疗推迟到百草枯给药后10小时，仍有80%的存活率。鉴于发现人肺切片与大鼠肺切片以相同方式蓄积百草枯这一结果，讨论了该治疗方法对人类百草枯中毒的相关性。
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