一名三氯乙烯成瘾患者尿液代谢物的排泄动力学
Excretion kinetics of urinary metabolites in a patient addicted to richloroethylene.
作者信息
Ikeda M, Otsuji H, Kawai H, Kuniyoshi M
出版信息
Br J Ind Med. 1971 Apr;28(2):203-6. doi: 10.1136/oem.28.2.203.
Abstract
203-206. A male Japanese subject, single, aged 38, who worked at a workshop washing metal parts with trichloroethylene, was admitted to our clinic due to addiction to the solvent. Analyses of urine revealed the presence of up to 160 μg/ml of trichloro-compounds (mostly trichloroacetic acid) which gradually disappeared in three weeks as the psychotic symptoms cleared up. The excretion half-lives of trichloroethylene metabolites for the initial rapid phase (succeeding slow phase in parentheses) were 5·8 (49·7) hours for trichloroethanol, 22·5 (72·6) hours for trichloroacetic acid, and 7·5 (72·6) hours for total trichloro-compounds.
摘要
203 - 206。一名38岁的日本单身男性，在一家用三氯乙烯清洗金属部件的工厂工作，因对该溶剂成瘾而入住我们的诊所。尿液分析显示，三氯化合物（主要是三氯乙酸）含量高达160μg/ml，随着精神症状的消失，这些化合物在三周内逐渐减少。三氯乙烯代谢物在初始快速阶段（括号内为随后的缓慢阶段）的排泄半衰期，三氯乙醇为5.8（49.7）小时，三氯乙酸为22.5（72.6）小时，总三氯化合物为7.5（72.6）小时。
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