刺激后白细胞中DNA胸腺嘧啶合成的替代途径。
Alternative pathways for DNA-thymine synthesis in stimulated leucocytes.
作者信息
Wolberg W H
出版信息
Clin Exp Immunol. 1971 Feb;8(2):177-86.
Abstract
transformation of stimulated lymphocytes is frequently evaluated from their ability to incorporate thymidine. This technique measures only one pathway by which cells synthesize DNA-thymine. The purpose of this study was to evaluate the incorporation of various precursors into the DNA-thymine of stimulated leucocytes. It was found that the uptake of thymidine did provide an adequate assessment of total precursor incorporation.
摘要
受刺激淋巴细胞的转化情况通常通过其掺入胸腺嘧啶核苷的能力来评估。这项技术仅测量细胞合成DNA - 胸腺嘧啶的一条途径。本研究的目的是评估各种前体掺入受刺激白细胞的DNA - 胸腺嘧啶中的情况。结果发现，胸腺嘧啶核苷的摄取确实能充分评估前体的总掺入情况。
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本文引用的文献
1
[A simple method for the quantitative determination of desoxyribonucleic acid in animal tissues].[一种定量测定动物组织中脱氧核糖核酸的简单方法]
Biokhimiia. 1961 Sep-Oct;26:834-9.
2
Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.植物血凝素：正常人白细胞培养中细胞有丝分裂的启动剂。
Cancer Res. 1960 May;20:462-6.
3
LYMPHOCYTE INTERACTION: A POTENTIAL HISTOCOMPATIBILITY TEST IN VITRO.淋巴细胞相互作用：一种潜在的体外组织相容性试验。
Science. 1964 Feb 21;143(3608):813-4. doi: 10.1126/science.143.3608.813.
4
STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. VI. THYMIDYLATE SYNTHETASE AND DEOXYCYTIDYLATE DEAMINASE.正常与白血病白细胞的研究。VI. 胸苷酸合成酶与脱氧胞苷酸脱氨酶
J Clin Invest. 1963 Dec;42(12):1913-21. doi: 10.1172/JCI104877.
5
6
7
8
Tritiated-thymidine uptake in mixed leucocyte cultures: effect of specific activity and exposure time.氚标记胸腺嘧啶核苷在混合白细胞培养物中的摄取：比活度和暴露时间的影响
Clin Exp Immunol. 1970 Feb;6(2):255-62.
9
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