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海蒽酮:一种移码诱变剂。

Hycanthone: a frameshift mutagen.

作者信息

Hartman P E, Levine K, Hartman Z, Berger H

出版信息

Science. 1971 Jun 4;172(3987):1058-60. doi: 10.1126/science.172.3987.1058.

DOI:10.1126/science.172.3987.1058
PMID:5573958
Abstract

Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.

摘要

抗血吸虫药的快速斑点试验筛选表明,海恩酮是一种强效的移码诱变剂,而与之密切相关的化合物米拉西啶D在沙门氏菌中无诱变作用。在大肠杆菌中生长期间,海恩酮和米拉西啶D对T4噬菌体均为移码诱变剂。

相似文献

1
Hycanthone: a frameshift mutagen.海蒽酮:一种移码诱变剂。
Science. 1971 Jun 4;172(3987):1058-60. doi: 10.1126/science.172.3987.1058.
2
Comparison of hycanthone ("etrenol"), some hycanthone analogs, myxin and 4-nitroquinoline-1-oxide as frameshift mutagens.
J Pharmacol Exp Ther. 1973 Sep;186(3):390-8.
3
Interaction of indazole analogs of lucanthone and hycanthone with closed circular duplex deoxyribonucleic acid.
J Pharmacol Exp Ther. 1973 Sep;186(3):385-9.
4
Comparative ability of hycanthone and miracil D to interact with DNA.
Science. 1971 Dec 10;174(4014):1147-8. doi: 10.1126/science.174.4014.1147.
5
Transformation of Rauscher virus-infected cell cultures after treatment with hycanthone and lucanthone.
J Pharmacol Exp Ther. 1973 Sep;186(3):425-9.
6
Comparative studies of the action of mirasan, lucanthone, hycanthone and niridazole against Schistosoma mansoni in mice.米拉萨、卢坎酮、海恩酮和硝唑咪对小鼠曼氏血吸虫作用的比较研究。
Ann Trop Med Parasitol. 1971 Mar;65(1):45-58. doi: 10.1080/00034983.1971.11686729.
7
Microsomal activation to mutagens of antischistosomal methyl thioxanthenones and initial tests on a possibly non-mutagenic analogue.
Mutat Res. 1975 Apr;31(2):87-95. doi: 10.1016/0165-1161(75)90070-9.
8
Hycanthone, a new active metabolite of lucanthone.
J Med Chem. 1967 Sep;10(5):867-76. doi: 10.1021/jm00317a025.
9
Mutagenic evaluation of antischistosomal drugs and their derivatives in Neurospora crassa.抗血吸虫药物及其衍生物在粗糙脉孢菌中的诱变评估。
J Toxicol Environ Health. 1975 Nov;1(2):271-9. doi: 10.1080/15287397509529326.
10
Early steps in mutagenesis by hycanthone.
Cancer Res. 1978 Mar;38(3):781-6.

引用本文的文献

1
Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators.基于细胞的AlphaLISA分析法用于小分子蛋白酶体调节剂高通量筛选的开发
ACS Omega. 2023 Apr 21;8(17):15650-15659. doi: 10.1021/acsomega.3c01158. eCollection 2023 May 2.
2
PZQ Therapy: How Close are we in the Development of Effective Alternative Anti-schistosomal Drugs?吡喹酮疗法:我们在有效替代抗血吸虫药物的研发上进展如何?
Infect Disord Drug Targets. 2019;19(4):337-349. doi: 10.2174/1871526519666181231153139.
3
The redox biology of schistosome parasites and applications for drug development.
血吸虫寄生虫的氧化还原生物学及其在药物开发中的应用。
Curr Pharm Des. 2012;18(24):3595-611.
4
Quantitative Measurement of the Ability of Different Mutagens to Induce an Inherited Change in Phenotype to Allow Maltose Utilization in Suspension Cultures of the Soybean, GLYCINE MAX (L.) Merr.不同诱变剂诱导表型遗传变化能力的定量测量,以使大豆悬浮培养物能够利用麦芽糖,大豆, Glycine max (L.) Merr。
Genetics. 1980 Sep;96(1):213-22. doi: 10.1093/genetics/96.1.213.
5
Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes.敌百虫和敌敌畏对血吸虫体内胆碱酯酶的抑制作用。
Br J Pharmacol. 1972 Nov;46(3):480-7. doi: 10.1111/j.1476-5381.1972.tb08145.x.
6
Miracil D: inhibition of deoxyribonucleic acid polymerase-deficient Escherichia coli.米拉西尔D:对缺乏脱氧核糖核酸聚合酶的大肠杆菌的抑制作用。
Antimicrob Agents Chemother. 1973 Apr;3(4):530-1. doi: 10.1128/AAC.3.4.530.
7
Induction of P22 prophage in Salmonella typhimurium by hycanthone.海恩酮对鼠伤寒沙门氏菌中P22原噬菌体的诱导作用。
J Virol. 1974 May;13(5):1153-4. doi: 10.1128/JVI.13.5.1153-1154.1974.
8
Metabolic activation of mutagens in mammals host-mediated assay utilizing the induction of mitotic gene conversion in Saccharomyces cerevisiae.利用酿酒酵母中有丝分裂基因转换的诱导在哺乳动物宿主介导试验中对诱变剂进行代谢活化。
Agents Actions. 1973 Jun;3(2):99-110. doi: 10.1007/BF01986541.
9
An improved bacterial test system for the detection and classification of mutagens and carcinogens.一种用于检测诱变剂和致癌物并对其进行分类的改良细菌检测系统。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6. doi: 10.1073/pnas.70.3.782.
10
Intestinal parasites.肠道寄生虫
Gut. 1973 Feb;14(2):145-68. doi: 10.1136/gut.14.2.145.