静脉注射异丙肾上腺素和沙丁胺醇对犬心肺功能的影响。
Cardiorespiratory effects of intravenous isoprenaline and salbutamol in dogs.
作者信息
Loh L, Seed R F, Sykes M K
出版信息
Br J Pharmacol. 1971 Mar;41(3):445-53. doi: 10.1111/j.1476-5381.1971.tb08042.x.
Abstract
- The cardiorespiratory effects of intravenous infusions of isoprenaline and salbutamol (1 and 5 mug/min) have been compared in twelve dogs.2. Both drugs produced a rise in pulse rate, a fall in systemic arterial pressure and a rise in pulmonary arterial pressure. Salbutamol produced a greater increase in cardiac output than isoprenaline.3. Both drugs produced an increase in venous admixture, but a significant fall in arterial oxygen tension occurred only with isoprenaline at the higher dose.
摘要
已对12只犬静脉输注异丙肾上腺素和沙丁胺醇（1和5微克/分钟）的心肺效应进行了比较。
两种药物均使心率升高、体动脉压下降及肺动脉压升高。沙丁胺醇使心输出量的增加幅度大于异丙肾上腺素。
两种药物均使静脉混合血增加，但仅高剂量异丙肾上腺素使动脉血氧张力显著下降。
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