利尿药氨苯蝶啶和汞撒利对离体蛙皮主动钠转运机制的影响。
Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin.
作者信息
Salako L A, Smith A J
出版信息
Br J Pharmacol. 1971 Mar;41(3):552-7. doi: 10.1111/j.1476-5381.1971.tb08053.x.
Abstract
- Triamterene reduces the rate coefficients for sodium movement into the transporting system of the isolated frog skin. The isotopically measured ;active sodium transport pool' is also reduced.2. Mersalyl reduces the rate coefficient for sodium and the calculated sodium flux from the transporting system to the inner bathing solution. The ;active sodium transport pool' is increased by this diuretic.3. The action of triamterene closely resembles that of amiloride and both reduce the entry of sodium into the system. In contrast, mersalyl limits the exit of sodium ions from the skin.
摘要
氨苯蝶啶降低了钠进入离体蛙皮转运系统的速率系数。通过同位素测量的“活性钠转运池”也减少了。
汞撒利降低了钠的速率系数以及从转运系统到内部浴液的计算钠通量。这种利尿剂会使“活性钠转运池”增加。
氨苯蝶啶的作用与阿米洛利非常相似，两者都减少了钠进入系统的量。相比之下，汞撒利限制了钠离子从皮肤排出。
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