氨氯吡咪对蛙皮钠池及钠转运动力学的影响。
Changes in sodium pool and kinetics of sodium transport in frog skin produced by amiloride.
作者信息
Salako L A, Smith A J
出版信息
Br J Pharmacol. 1970 May;39(1):99-109. doi: 10.1111/j.1476-5381.1970.tb09559.x.
Abstract
- Amiloride produces a decrease in size of the active sodium transport pool of isolated frog skin.2. Rate coefficients for sodium movement into and out of the transporting cells across the outside membrane are decreased by amiloride. The rate coefficient for sodium extrusion across the inside membrane is not significantly affected.3. In the presence and in the absence of amiloride, the relation of sodium transport to outside sodium concentration exhibits similar saturation kinetics but amiloride reduces sodium transport rate at every sodium concentration of the outside solution.4. Labelling of skin with (14)C-amiloride from the outside solution is significantly greater than labelling with (14)C-inulin.5. The results of these studies suggest that amiloride reacts with sites on the outside membrane of the transporting cells as a result of which the rate of sodium movement across this membrane is diminished.
摘要
氨氯吡咪可使离体蛙皮活性钠转运池的大小减小。
氨氯吡咪可降低钠穿过外侧膜进出转运细胞的速率系数。钠穿过内侧膜的外排速率系数未受到显著影响。
在有和没有氨氯吡咪存在的情况下，钠转运与外侧钠浓度的关系呈现出相似的饱和动力学，但氨氯吡咪会降低外侧溶液中每个钠浓度下的钠转运速率。
从外侧溶液用（14）C-氨氯吡咪标记皮肤的程度明显大于用（14）C-菊粉标记的程度。
这些研究结果表明，氨氯吡咪与转运细胞外侧膜上的位点发生反应，其结果是钠穿过该膜的速率降低。
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