氨氯吡咪对离体蛙皮主动钠转运的作用：关于作用部位的证据
Effects of amiloride on active sodium transport by the isolated frog skin: evidence concerning site of action.
作者信息
Salako L A, Smith A J
出版信息
Br J Pharmacol. 1970 Apr;38(4):702-18. doi: 10.1111/j.1476-5381.1970.tb09878.x.
Abstract
- Amiloride reduces short-circuit current and potential difference across the isolated frog skin.2. Isotopically measured sodium influx and efflux are diminished.3. Total electrical conductance and partial sodium conductance are diminished, the reduction in total conductance being entirely accounted for by the reduction in partial sodium conductance.4. The effect of antidiuretic hormone (ADH), cyclic 3'5'-adenosine monophosphate (cyclic AMP) and theophylline can be antagonized by pretreatment with amiloride but the antagonism can be abolished by increasing the concentration of these compounds.5. Amiloride has no effect on oxygen consumption in concentrations which inhibit sodium transport. However, it prevents the stimulatory effect of ADH on oxygen consumption.6. The results are consistent with an action of amiloride at the passive outside membrane of the transporting cells of isolated frog skin.
摘要
氨氯吡咪可降低离体蛙皮的短路电流和电位差。
同位素测定的钠流入和流出减少。
总电导和部分钠电导降低，总电导的降低完全由部分钠电导的降低所致。
抗利尿激素（ADH）、环磷腺苷（cAMP）和茶碱的作用可被氨氯吡咪预处理拮抗，但通过增加这些化合物的浓度可消除这种拮抗作用。
氨氯吡咪在抑制钠转运的浓度下对氧消耗无影响。然而，它可防止ADH对氧消耗的刺激作用。
这些结果与氨氯吡咪在离体蛙皮转运细胞的被动外膜上的作用一致。
相似文献
1
Effects of amiloride on active sodium transport by the isolated frog skin: evidence concerning site of action.氨氯吡咪对离体蛙皮主动钠转运的作用：关于作用部位的证据
Br J Pharmacol. 1970 Apr;38(4):702-18. doi: 10.1111/j.1476-5381.1970.tb09878.x.
2
Changes in sodium pool and kinetics of sodium transport in frog skin produced by amiloride.氨氯吡咪对蛙皮钠池及钠转运动力学的影响。
Br J Pharmacol. 1970 May;39(1):99-109. doi: 10.1111/j.1476-5381.1970.tb09559.x.
3
Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin.利尿药氨苯蝶啶和汞撒利对离体蛙皮主动钠转运机制的影响。
Br J Pharmacol. 1971 Mar;41(3):552-7. doi: 10.1111/j.1476-5381.1971.tb08053.x.
4
Independent action of antidiuretic hormone, theophylline and cyclic 3',5'-adenosine monophosphate on cell membrane permeability in frog skin.抗利尿激素、茶碱和环3',5'-腺苷单磷酸对蛙皮细胞膜通透性的独立作用
J Physiol. 1968 Dec;199(3):593-612. doi: 10.1113/jphysiol.1968.sp008670.
5
Reduction of chloride fluxes by amiloride across the short-circuited frog skin.氨氯吡咪对短路蛙皮氯通量的降低作用。
Am J Physiol. 1978 May;234(5):F437-45. doi: 10.1152/ajprenal.1978.234.5.F437.
6
Amiloride: a potent inhibitor of sodium transport across the toad bladder.氨氯地平：蟾蜍膀胱钠转运的强效抑制剂。
J Physiol. 1968 Mar;195(2):317-30. doi: 10.1113/jphysiol.1968.sp008460.
7
The effects of anions on sodium transport.阴离子对钠转运的影响。
Br J Pharmacol. 1969 May;36(1):97-106. doi: 10.1111/j.1476-5381.1969.tb08307.x.
8
Effect of furosemide on sodium transport in frog skin. Interaction with amiloride and ouabain.呋塞米对蛙皮钠转运的影响。与阿米洛利和哇巴因的相互作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;280(1):12-38. doi: 10.1007/BF00505352.
9
Amiloride and the mode of action of aldosterone on sodium transport across toad bladder and skin.氨氯吡脒与醛固酮对蟾蜍膀胱和皮肤钠转运的作用方式
Pflugers Arch. 1968;304(3):284-96. doi: 10.1007/BF00592131.
10
Effect of amiloride on chloride transport across amphibian epithelia.氨氯吡咪对氯离子跨两栖类上皮细胞转运的影响。
J Membr Biol. 1978;40 Spec No:167-85. doi: 10.1007/BF02026004.
引用本文的文献
1
Control of sodium permeability of the outer barrier in toad skin.蟾蜍皮肤外层屏障钠通透性的控制
J Membr Biol. 1982;66(2):97-107. doi: 10.1007/BF01868486.
2
Relationship of transient electrical properties to active sodium transport by toad urinary bladder.蟾蜍膀胱瞬态电特性与活性钠转运的关系。
J Membr Biol. 1980 Jan 31;52(1):25-35. doi: 10.1007/BF01869003.
3
Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin.利尿药氨苯蝶啶和汞撒利对离体蛙皮主动钠转运机制的影响。
Br J Pharmacol. 1971 Mar;41(3):552-7. doi: 10.1111/j.1476-5381.1971.tb08053.x.
4
Effect of changes in transepithelial transport on the uptake of sodium across the outer surface of the frog skin.跨上皮转运变化对蛙皮外表面钠摄取的影响。
J Gen Physiol. 1971 Aug;58(2):131-44. doi: 10.1085/jgp.58.2.131.
5
Absorption, distribution and elimination of 14 C-amiloride in normal human subjects.14C-氨氯地平在正常人体受试者中的吸收、分布和消除。
Br J Pharmacol. 1971 Oct;43(2):473P-474P.
6
Computer simulation of sodium fluxes in frog skin epidermis.蛙皮表皮钠通量的计算机模拟。
J Membr Biol. 1974;15(1):47-66. doi: 10.1007/BF01870081.
7
Kinetics and bioavailability of two formulations of amiloride in man.氨氯吡咪两种制剂在人体中的动力学和生物利用度
Br J Pharmacol. 1973 Aug;48(4):646-9.
8
The mechanism of lithium accumulation in the isolated frog skin epithelium.锂在离体蛙皮上皮细胞中蓄积的机制。
Pflugers Arch. 1972;337(1):1-18. doi: 10.1007/BF00587867.
9
An upper limit to the number of sodium channels in frog skin epithelium.蛙皮上皮细胞中钠通道数量的上限。
J Physiol. 1973 Feb;228(3):681-92. doi: 10.1113/jphysiol.1973.sp010106.
10
Sodium uptake by frog skin and its modification by inhibitors of transepithelial sodium transport.蛙皮对钠的摄取及其经上皮钠转运抑制剂的调节作用。
J Physiol. 1973 Jan;228(1):221-39. doi: 10.1113/jphysiol.1973.sp010083.
本文引用的文献
1
2
Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.钠的主动转运作为短路离体蛙皮电流的来源。
Acta Physiol Scand. 1951 Aug 25;23(2-3):110-27. doi: 10.1111/j.1748-1716.1951.tb00800.x.
3
The similarity of effects of vasopressin, adenosine-3',5'-phosphate (cyclic AMP) and theophylline on the toad bladder.血管加压素、腺苷 - 3',5'-磷酸（环磷酸腺苷）和茶碱对蟾蜍膀胱作用的相似性。
J Clin Invest. 1962 Apr;41(4):702-9. doi: 10.1172/JCI104528.
4
5
NATURE OF SHUNT PATH AND ACTIVE SODIUM TRANSPORT PATH THROUGH FROG SKIN EPITHELIUM.通过蛙皮上皮的分流途径和活性钠转运途径的性质。
Acta Physiol Scand. 1964 Aug;61:484-504.
6
The effect of Ca and antidiuretic hormone on Na transport across frog skin. II. Sites and mechanisms of action.钙和抗利尿激素对蛙皮钠转运的影响。II. 作用位点与作用机制。
J Gen Physiol. 1963 May;46(5):1011-27. doi: 10.1085/jgp.46.5.1011.
7
The effect of Ca and antidiuretic hormone on Na transport across frog skin. I. Examination of interrelationships between Ca and hormone.钙和抗利尿激素对蛙皮钠转运的影响。I. 钙与激素之间相互关系的研究。
J Gen Physiol. 1963 May;46(5):999-1010. doi: 10.1085/jgp.46.5.999.
8
The effect of calcium on sodium transport by frog skin.钙对蛙皮钠转运的影响。
J Gen Physiol. 1962 Mar;45(4):625-41. doi: 10.1085/jgp.45.4.625.
9
Investigations on the effect of some local anaesthetics and other amines on the active transport of sodium through the isolated short-circuited frog skin.关于某些局部麻醉剂和其他胺类对钠通过离体短路蛙皮的主动转运影响的研究。
Biochim Biophys Acta. 1959 Oct;35:324-33. doi: 10.1016/0006-3002(59)90381-6.
Zotero 插件