由预先存在的对胎牛血清的超敏反应所诱导的体外淋巴细胞转化

In vitro lymphocyte transformation induced by pre-existing hypersensitivity to foetal calf serum.

作者信息

Howe M L, Battisto J R

出版信息

Clin Exp Immunol. 1971 Apr;8(4):617-23.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712961/

Abstract

Certain foetal calf sera (FCS), upon initial injection, elicit delayed dermal reactions in some but not all guinea-pigs. The FCS that evoke significant dermal responses also initiate blastogenesis of lymphocytes taken from animals exhibiting the dermal reactions. A correlation exists between the severity of the reactions and the degree of blastogenesis observed. An explanation for these observations has been suggested, i.e. that some guinea-pigs possess spontaneously developed delayed hypersensitivity for antigen(s) contained in FCS.

摘要

某些胎牛血清（FCS）在初次注射时，会在部分而非所有豚鼠中引发延迟性皮肤反应。引发显著皮肤反应的FCS也会引发表现出皮肤反应的动物淋巴细胞的母细胞生成。反应的严重程度与所观察到的母细胞生成程度之间存在相关性。针对这些观察结果已提出一种解释，即一些豚鼠对FCS中所含抗原具有自发形成的迟发型超敏反应。

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THE DEVELOPMENT OF LARGE IMMATURE MONONUCLEAR CELLS IN MIXED LEUKOCYTE CULTURES.混合白细胞培养中大型未成熟单核细胞的发育

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Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢

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The necrotic lesion in guinea-pig skin produced by certain human sera.某些人血清在豚鼠皮肤上产生的坏死性病变。

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Spontaneous lymphocyte transformation in vitro: negative evidence from a study of thymidine uptake.体外自发性淋巴细胞转化：一项关于胸苷摄取研究的阴性证据

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Reaction of human lymphocytes in culture to components of the medium.培养中的人淋巴细胞对培养基成分的反应。

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Reactivity of human lymphocytes to autologous and homologous serum.

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Spontaneous delayed iso-hypersensitivity in guinea pigs.豚鼠的自发性迟发型同种超敏反应。

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Lymphocytes of small mammals: spontaneous transformation in culture to blastoids.

Science. 1965 Sep 17;149(3690):1385-7. doi: 10.1126/science.149.3690.1385.

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Spontaneous "transformation" of lymphocytes from the umbilical-cord vein.

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The local response in the guinea-pig to self and non-self proteins.豚鼠对自身和非自身蛋白质的局部反应。

Immunology. 1965 Sep;9(3):235-40.

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