Norton W, Ziff M
Immunology. 1965 Sep;9(3):235-40.
Foreign proteins have been compared with their corresponding isologous and autologous proteins with respect to their capacity to induce inflammatory reactions at the site of injection in the skin. In contrast to the foreign proteins, which consistently produced mild reactions which were morphologically similar to the delayed hypersensitivity reaction, autologous and isologous proteins failed to induce local accumulations of inflammatory cells. The capacity of cells at the inflammatory site to phagocytoze heterologous and isologous ferritin was investigated in the electron microscope, and no qualitative differences were noted. The results are interpreted as evidence for the existence of a local mechanism capable of differentiating between foreign and autologous protein. The possible significance and role of such a mechanism is discussed.
已针对在皮肤注射部位诱导炎症反应的能力，将外源蛋白与其相应的同种和自体蛋白进行了比较。与始终引发形态上类似于迟发型超敏反应的轻微反应的外源蛋白不同，自体和同种蛋白未能诱导炎症细胞的局部聚集。利用电子显微镜研究了炎症部位细胞吞噬异种和同种铁蛋白的能力，未发现定性差异。这些结果被解释为存在一种能够区分外源蛋白和自体蛋白的局部机制的证据。讨论了这种机制可能的意义和作用。
