小脑计算的可靠性。
Reliability of computation in the cerebellum.
作者信息
Sabah N H
出版信息
Biophys J. 1971 May;11(5):429-45. doi: 10.1016/S0006-3495(71)86226-4.
The mossy fiber-granule cell-parallel fiber-Purkinje cell system of the cerebellar cortex is investigated from the viewpoint of reliability of computation. It is shown that the effects of variability in the inputs to a Purkinje cell can be reduced by having a large number of parallel fibers whose activities are statistically independent. The mossy fiber-granule cell relay is shown to be capable of performing the required function of transforming the activity in a small number of mossy fibers into activity in a much larger number of parallel fibers, while ensuring that there is little correlation between the activities of individual parallel fibers. The effects of variability in the outputs of Purkinje cells may be reduced by redundancy and convergence schemes, as evidenced by the geometrical pattern of parallel fibers and Purkinje cells and the convergence of these cells onto their target neurons.
从小脑皮质的苔藓纤维 - 颗粒细胞 - 平行纤维 - 浦肯野细胞系统的计算可靠性角度进行了研究。结果表明，通过拥有大量活动在统计上相互独立的平行纤维，可以降低输入到浦肯野细胞的变异性影响。苔藓纤维 - 颗粒细胞中继被证明能够执行所需的功能，即将少量苔藓纤维中的活动转化为大量平行纤维中的活动，同时确保各个平行纤维的活动之间几乎没有相关性。浦肯野细胞输出的变异性影响可以通过冗余和汇聚方案来降低，平行纤维和浦肯野细胞的几何模式以及这些细胞向其目标神经元的汇聚证明了这一点。
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