取代腺苷类似物的心血管作用。
Cardiovascular actions of substituted adenosine analogues.
作者信息
Angus J A, Cobbin L B, Einstein R, Maguire M H
出版信息
Br J Pharmacol. 1971 Apr;41(4):592-9. doi: 10.1111/j.1476-5381.1971.tb07067.x.
Abstract
- The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open-thorax dogs.2. The potency and duration of action of substituted adenosine analogues were compared with that of adenosine.3. With the exception of 2-chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2-position of the adenosine molecule reduced activity.4. In all cases 2-substitution prolonged the duration of the coronary dilator activity of adenosine.5. N(6)-Methylation of adenosine and 2-chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response.6. Comparison of the coronary dilator potencies and hypotensive activities of 2-ethylaminoadenosine and 2-methoxyadenosine indicates that these analogues have some specificity for the coronary bed.
摘要
在麻醉开胸犬身上研究了腺苷对全身血压、冠状动脉血流量、心肌收缩力及心率的影响。
将取代的腺苷类似物的作用强度和持续时间与腺苷进行了比较。
除2 - 氯腺苷的冠状动脉扩张活性增强外，腺苷分子2位上的取代降低了活性。
在所有情况下，2位取代延长了腺苷冠状动脉扩张活性的持续时间。
腺苷和2 - 氯腺苷的N(6)-甲基化降低了它们的冠状动脉扩张活性，但对反应持续时间无影响。
2 - 乙氨基腺苷和2 - 甲氧基腺苷的冠状动脉扩张效力和降压活性比较表明，这些类似物对冠状动脉床有一定特异性。
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Cardiovascular actions of substituted adenosine analogues.取代腺苷类似物的心血管作用。
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本文引用的文献
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J Physiol. 1929 Nov 25;68(3):213-37. doi: 10.1113/jphysiol.1929.sp002608.
2
The systemic and coronary hemodynamic effects of adenosine triphosphate and adenosine.三磷酸腺苷和腺苷对全身及冠状动脉血流动力学的影响。
Am Heart J. 1962 Aug;64:228-34. doi: 10.1016/0002-8703(62)90334-4.
3
INFLUENCE OF A PYRIMIDOPYRIMIDINE DERIVATIVE ON DEAMINATION OF ADENOSINE BY BLOOD.一种嘧啶并嘧啶衍生物对血液中腺苷脱氨基作用的影响。
Circ Res. 1964 Jul;15:83-8. doi: 10.1161/01.res.15.1.83.
4
5
A study of the cardiovascular actions of 2-chloroadenosine.2-氯腺苷的心血管作用研究。
Arch Int Pharmacodyn Ther. 1959 Jan 1;118(1-2):95-106.
6
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Circ Res. 1956 May;4(3):343-8. doi: 10.1161/01.res.4.3.343.
7
Coronary dilator action of the adenine-ATP series.腺嘌呤 - 三磷酸腺苷系列的冠状动脉扩张作用。
J Pharmacol Exp Ther. 1953 Nov;109(3):255-60.
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Enzymatic deamination and vasodepressor effects of adenosine analogs.腺苷类似物的酶促脱氨基作用和血管降压效应。
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