应激和倍他米松对大鼠肾上腺体外分泌皮质酮的影响。
Effects of stress and betamethasone on the production of corticosterone by the rat adrenal gland in vitro.
作者信息
Hodges J R, Mitchley S
出版信息
Br J Pharmacol. 1971 Apr;41(4):640-7. doi: 10.1111/j.1476-5381.1971.tb07072.x.
Abstract
- Production of corticosterone in vitro was studied using adrenal glands from rats which had been subjected to stress or treated with betamethasone.2. An increase in corticosterone production occurred in the first but not the second hour of incubation in adrenals removed immediately after stress. When the interval between stress and adrenalectomy was longer, the increased corticosterone production persisted.3. Betamethasone had no effect on corticosteroidogenesis in vitro when added directly to the incubation medium or when administered to rats shortly before removal of their adrenal glands.4. Corticosteroidogenesis in vitro was considerably reduced in the adrenals of rats given prolonged treatment with betamethasone.5. The significance of the results and the reliability of in vitro corticosteroid production as an index of hypothalamo-pituitary-adrenal activity is discussed.
摘要
使用遭受应激或接受倍他米松治疗的大鼠的肾上腺，研究了体外皮质酮的产生。
应激后立即摘除的肾上腺在孵育的第一个小时而非第二个小时皮质酮产量增加。当应激与肾上腺切除术之间的间隔时间更长时，皮质酮产量的增加持续存在。
当直接添加到孵育培养基中或在摘除肾上腺前不久给大鼠给药时，倍他米松对体外皮质类固醇生成没有影响。
长期接受倍他米松治疗的大鼠的肾上腺中，体外皮质类固醇生成显著降低。
讨论了结果的意义以及体外皮质类固醇产生作为下丘脑 - 垂体 - 肾上腺活动指标的可靠性。
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