Calorimetric measurements of the transition enthalpy of DNA in aqueous urea solutions.
作者信息
Klump H, Burkart W
出版信息
Biochim Biophys Acta. 1977 Apr 19;475(4):601-4. doi: 10.1016/0005-2787(77)90320-3.
PMID:557993
Abstract
The helix-coil equilibrium of DNA is delicately affected by the nature of the solvent. In this investigation the helical secondary structure was destabilized by an increasing concentration of urea. We found a linear dependence of the transition enthalpy deltaH on the urea concentration for calf thymus DNA as well as for salmon sperm DNA.
摘要
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