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[完整及去传入神经下丘脑对大鼠慢性刺激对脂质代谢和肾上腺皮质的影响]

[Effect of chronic stimulation of rats with intact and deafferented hypothalamuses on lipid metabolism and the adrenal cortex].

作者信息

Ryzhenkov V E, Sapronov N S, Khechinashvili G G, Mosina I V, Oletskaia T A

出版信息

Biull Eksp Biol Med. 1977 Mar;83(3):289-91.

PMID:558018
Abstract

Chronic irritation of the falsely operated rats and those with the deafferentated hypothalamus led to reduction of total blood cholesterol and the accumulation of triglycerides in the liver. Dexamethasone administration was accompanied by an increase of blood cholesterol and triglycerides and the triglyceride accumulation in the liver. The action of dexamethasone was more pronounced in the animals with the deafferentated hypothalamus. The rate of 11-oxycorticosteroid secretion into the adrenal vein is reduced in the latter.

摘要

对假手术大鼠和下丘脑传入神经切断的大鼠进行慢性刺激,会导致总血胆固醇降低以及肝脏中甘油三酯的积累。给予地塞米松会伴随血胆固醇和甘油三酯增加以及肝脏中甘油三酯的积累。地塞米松对下丘脑传入神经切断的动物作用更为明显。后者肾上腺静脉中11-氧皮质类固醇的分泌速率降低。

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