Muraoka Y, Itoh M, Maeda Y, Hayashi Y
Jikken Dobutsu. 1977 Jan;26(1):1-12. doi: 10.1538/expanim1957.26.1_1.
Age-related histological changes were studied in various organs from SD-JCL rats reared throughout their lifespan. In aged-male rats examined at 5 to 36 months of age were frequently observed nephropathy, periarteritis, skeletal muscle degeneration, pigmentation of the follicular epithelium in the thyroid, fibrosis of the pancreatic islets, hyperplasia of the parathyroid epithelium, and changes of the acini in the extraorbital lacrymal gland. In aged-female rats sinusoid dilatation of the adrenal, and atrophy of the ovary were also noted. Perilobular fat deposition of the liver, dilatation of the gastric gland and severe hemosiderosis of the spleen were observed similar frequency in the both sexes. The nephropathy and cardiovasculopathy were major factors to cause death for males, while the main cause of death for females was tumors, especially of the mammary and pituitary glands. Enlargement of the parathyroid gland, bone resorption and metastatic calcification in the solf tissues were found in rats with severe nephropathy.
对整个生命周期饲养的SD-JCL大鼠的各种器官进行了与年龄相关的组织学变化研究。在5至36月龄的老年雄性大鼠中，经常观察到肾病、动脉周围炎、骨骼肌变性、甲状腺滤泡上皮色素沉着、胰岛纤维化、甲状旁腺上皮增生以及眶外泪腺腺泡变化。在老年雌性大鼠中，还观察到肾上腺血窦扩张和卵巢萎缩。两性肝脏小叶周围脂肪沉积、胃腺扩张和脾脏严重含铁血黄素沉着的发生率相似。肾病和心血管疾病是雄性大鼠死亡的主要因素，而雌性大鼠的主要死因是肿瘤，尤其是乳腺和垂体肿瘤。在患有严重肾病的大鼠中发现甲状旁腺肿大、骨吸收和软组织转移性钙化。
