[2-邻碘酪氨酸]-催产素和[2-邻甲基酪氨酸]-催产素：基础药理学及其在结合研究中潜在用途的评论
[2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: basic pharmacology and comments on their potential use in binding studies.
作者信息
Pliska V, Marbach P, Vasák J, Rudinger J
出版信息
Experientia. 1977 Mar 15;33(3):367-9. doi: 10.1007/BF02002831.
PMID:558109
Abstract
Both [2-o-iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin display only weak vasopressor and antidiuretic effects on rats. They inhibit the in vitro uterotonic action of oxytocin; this inhibition is not fully competitive. It is concluded that they are not suitable as markers for studies of uterine receptor for oxytocin.
摘要
[2 - O - 碘酪氨酸] - 催产素和[2 - O - 甲基酪氨酸] - 催产素对大鼠仅表现出微弱的升压和抗利尿作用。它们抑制催产素的体外子宫收缩作用；这种抑制并非完全竞争性的。得出的结论是，它们不适用于作为研究催产素子宫受体的标记物。
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