Glucksmann A, Cherry C P
Br J Cancer. 1971 Mar;25(1):212-24. doi: 10.1038/bjc.1971.28.
At low concentrations of DMBA (½% and 1%) twice as many sarcomas and carcinomas of the salivary glands are induced in male as in female rats. Additional oestrogens reduce neoplasms in males by one half while testosterone doubles them in females. The sex difference disappears at the higher dose levels of the carcinogen (2%).Females are more sensitive than males to the toxic effects of DMBA, though less sensitive to the carcinogenic action.Carcinomas rise to a single peak within 240 days while sarcomas appear as late as 770 days with secondary and tertiary peaks. This difference in pattern of induction may be due to the formation of a fibrous capsule separating persisting DMBA-deposits from the epithelial structures and thus protecting them from carcinogenic risk.
在低浓度的二甲基苯蒽（DMBA，0.5%和1%）作用下，雄性大鼠唾液腺诱发的肉瘤和癌的数量是雌性大鼠的两倍。额外的雌激素可使雄性大鼠的肿瘤数量减少一半，而睾酮则使雌性大鼠的肿瘤数量增加一倍。在较高剂量的致癌物（2%）作用下，性别差异消失。雌性大鼠对DMBA的毒性作用比雄性大鼠更敏感，尽管对致癌作用的敏感性较低。癌在240天内升至单个峰值，而肉瘤则在770天才出现，还有第二和第三峰值。这种诱导模式的差异可能是由于形成了一个纤维性包膜，将持续存在的DMBA沉积物与上皮结构分隔开，从而保护它们免受致癌风险。
