Lewis P J, Kohner E M, Petrie A, Dollery C T
Lancet. 1976 Mar 13;1(7959):564-6. doi: 10.1016/s0140-6736(76)90359-7.
Glucose tolerance was investigated in 51 hypertensive patients before and after 1 and 6 years of treatment with oral diuretics. Glucose tolerance was unchanged after 1 year but had deteriorated significantly after 6 years' therapy. In a comparable group of 16 patients tested at similar intervals in which diuretic therapy had been given only for 3 of the 6 years there was no change in glucose tolerance, suggesting that prolonged oral treatment with thiazide diuretics is diabetogenic.
对51例高血压患者在口服利尿剂治疗1年和6年前后的糖耐量进行了研究。1年后糖耐量未变，但6年治疗后显著恶化。在一组16例类似的患者中，以相似的间隔进行检测，其中利尿剂治疗仅在6年中的3年进行，糖耐量没有变化，这表明长期口服噻嗪类利尿剂会导致糖尿病。
