钾钙通道和碳酸酐酶在噻嗪类药物诱导的高血糖中起作用吗？
Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
作者信息
Pickkers P, Schachter M, Sever P S, Hughes A D
机构信息
Department of Clinical Pharmacology, Queen Elizabeth the Queen Mother Wing, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, UK.
出版信息
J Hum Hypertens. 1995 Aug;9(8):691-3.
PMID:8523393
Abstract
Thiazide diuretics are widely used to treat hypertension, but their use is associated with impaired glucose tolerance. We propose that the diabetogenic action of thiazides may be due to their ability to open calcium-activated potassium (KCa) channels in pancreatic beta-cells.
摘要
噻嗪类利尿剂被广泛用于治疗高血压，但其使用与糖耐量受损有关。我们提出，噻嗪类药物的致糖尿病作用可能归因于它们开启胰腺β细胞中钙激活钾（KCa）通道的能力。
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