Giugliano D, Torella R, Sgambato S, D'Onofrio F
Diabetologia. 1980 Apr;18(4):293-6. doi: 10.1007/BF00251008.
This study aimed at evaluating the influence of furosemide upon insulin and glucagon responses to arginine in healthy subjects. For this purpose, six normal subjects received two consecutive arginine pulses (3 g), 60 min apart, before and after the administration of furosemide (40 mg, IV). The acute insulin response (mean change from 3-10 min) to the second arginine pulse was significantly inhibited by furosemide (mean increase: 14.8 +/- 3.0 microU/ml versus 11.7 +/- 2.5 microU/ml, p < 0.01). By contrast, the acute glucagon response was significantly increased (mean increase: 77 +/- 18 pg/ml versus 105 +/- 21 pg/ml, p < 0.01). No significant changes in plasma glucose levels occurred. In control experiments, in which saline rather than furosemide was administered, the acute insulin and glucagon response to the first arginine pulse did not differ from that observed with the second pulse. The effect of furosemide on insulin and glucagon secretion might be mediated through enhanced release of endogenous prostaglandin E.
本研究旨在评估速尿对健康受试者胰岛素及胰高血糖素对精氨酸反应的影响。为此，六名正常受试者在静脉注射速尿（40mg）前后，相隔60分钟连续接受两次精氨酸脉冲（3g）。速尿显著抑制了对第二次精氨酸脉冲的急性胰岛素反应（3 - 10分钟的平均变化）（平均增加值：14.8±3.0微单位/毫升对11.7±2.5微单位/毫升，p<0.01）。相比之下，急性胰高血糖素反应显著增加（平均增加值：77±18皮克/毫升对105±21皮克/毫升，p<0.01）。血浆葡萄糖水平未发生显著变化。在给予生理盐水而非速尿的对照实验中，对第一次精氨酸脉冲的急性胰岛素和胰高血糖素反应与第二次脉冲时观察到的反应无差异。速尿对胰岛素和胰高血糖素分泌的影响可能是通过内源性前列腺素E的释放增加介导的。
