饮食对新生大鼠肝脏葡萄糖激酶发育的调节
Regulation of development of hepatic glucokinase in the neonatal rat by the diet.
作者信息
Walker D G, Eaton S W
出版信息
Biochem J. 1967 Nov;105(2):771-7. doi: 10.1042/bj1050771.
Abstract
- Feeding a high-glucose diet to weanling rats showed that high hepatic glucokinase activities could be induced at 18 days of age, i.e. 2 days after development of the enzyme begins. 2. The normal development of glucokinase activity can be retarded by weaning rats on to carbohydrate-free, high-fat and high-protein diets. 3. Precocious development of the enzyme before 16 days of age cannot be induced by oral glucose administration. 4. It is concluded that the ability to synthesize glucokinase develops very rapidly and that the nature of the diet determines the normal developmental pattern.
摘要
- 给断乳大鼠喂食高糖饮食表明，在18日龄时可诱导出高肝葡萄糖激酶活性，即该酶开始发育2天后。2. 将大鼠断奶后喂食无碳水化合物、高脂肪和高蛋白饮食可延缓葡萄糖激酶活性的正常发育。3. 16日龄前口服葡萄糖不能诱导该酶过早发育。4. 得出的结论是，合成葡萄糖激酶的能力发育非常迅速，且饮食性质决定正常发育模式。
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