α-鹅膏蕈碱致肝坏死的发病机制研究。α-鹅膏蕈碱对小鼠肝细胞核核糖核酸合成及核糖核酸聚合酶的影响。
Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.
作者信息
Stirpe F, Fiume L
出版信息
Biochem J. 1967 Nov;105(2):779-82. doi: 10.1042/bj1050779.
Abstract
- Injection of alpha-amanitin to mice causes a decreased incorporation of [6-(14)C]-orotic acid into liver RNA in vivo. 2. The activity of RNA polymerase activated by Mn(2+) and ammonium sulphate is greatly impaired in liver nuclei isolated from mice poisoned with alpha-amanitin, and is inhibited by the addition of the same toxin in vitro. 3. The activity of the Mg(2+)-activated RNA polymerase is only slightly affected by alpha-amanitin either administered to mice or added in vitro.
摘要
- 给小鼠注射α-鹅膏蕈碱会导致体内[6-(14)C]-乳清酸掺入肝脏RNA的量减少。2. 用α-鹅膏蕈碱中毒的小鼠分离出的肝细胞核中，由锰离子和硫酸铵激活的RNA聚合酶活性受到极大损害，并且在体外添加相同毒素时会受到抑制。3. 镁离子激活的RNA聚合酶活性仅受到给小鼠注射α-鹅膏蕈碱或在体外添加该毒素的轻微影响。
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Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.α-鹅膏蕈碱致肝坏死的发病机制研究。α-鹅膏蕈碱对小鼠肝细胞核核糖核酸合成及核糖核酸聚合酶的影响。
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