Martin J T, Laskowski M B, Fenichel G M
Neurology. 1977 May;27(5):484-9. doi: 10.1212/wnl.27.5.484.
An acetylcholine-mediated myopathy has been produced in the soleus muscle of the rat by the daily injection of imidazole, a compound that accelerates the metabolism of adenosine 3':5' cyclic phosphate by activating the enzyme phosphodiesterase. The imidazole-treated muscles were found to have a lowered resting membrane potential. This study suggests that a decrease in resting membrane potential may make skeletal muscle more vulnerable to necrosis by acetylcholine released during normal activity.
通过每日注射咪唑，在大鼠的比目鱼肌中产生了一种乙酰胆碱介导的肌病。咪唑是一种通过激活磷酸二酯酶来加速3':5'环磷酸腺苷代谢的化合物。经咪唑处理的肌肉被发现静息膜电位降低。这项研究表明，静息膜电位的降低可能会使骨骼肌在正常活动期间因释放的乙酰胆碱而更容易发生坏死。
