Shields R, Smith J A
J Cell Physiol. 1977 Jun;91(3):345-55. doi: 10.1002/jcp.1040910304.
The proliferation of 3T3, 3T6 and SV3T3 cells was examined by time lapse cinephotography under a number of different growth conditions. It was found that the frequency distributions of intermitotic times of cells with widely different proliferation rates are qualitatively and quantitatively explained by the transition probability model of the cell cycle (Smith and Martin, '73). The behaviour of quiescent cells was characterized by very low values of the transition probability. No "out of cycle" or GO compartment of cells was detectable. From a consideration of these results and those in the literature it appears that the rate of cell proliferation is determined by the value of the "transition probability" (P), and that it is the biochemical manifestation of this parameter that regulates cell growth in vitro and in vivo.
在多种不同生长条件下，通过延时电影摄影术对3T3、3T6和SV3T3细胞的增殖进行了检测。结果发现，细胞周期的转变概率模型（Smith和Martin，1973年）在定性和定量上解释了增殖速率差异很大的细胞的有丝分裂间期时间的频率分布。静止细胞的行为特征是转变概率值非常低。未检测到细胞的“脱离周期”或G0期隔室。综合考虑这些结果以及文献中的结果，似乎细胞增殖速率由“转变概率”（P）的值决定，并且正是该参数的生化表现调节了体外和体内的细胞生长。
