Luderschmidt C, Plewig G
Arch Dermatol Res (1975). 1977 Apr 27;258(2):185-91. doi: 10.1007/BF00561624.
The Syrian hamster ear model was used to study effects of the anti-androgen cyproterone acetate and of the anti-lipogenic compound 17beta-carboxylic acid methyl ester and its ethyl ester. The steroid derivatives were applied topically in a 1-2% concentration or given systemically. Response of sebaceous gland was measured by means of cell proliferation (3H-TdR autoradiography) and by gland size (histoplanimetry). Cyproterone acetate significantly reduced the labelling and the planimetric value, both topically and systemically. The carboxylic acid derivatives, which block the 5alpha-reductase were ineffective. The new animal model is a sensitive and suitable means to study inhibition of sebum production.
采用叙利亚仓鼠耳部模型研究抗雄激素醋酸环丙孕酮以及抗脂肪生成化合物17β - 羧酸甲酯及其乙酯的作用。这些类固醇衍生物以1 - 2%的浓度局部应用或全身给药。通过细胞增殖（3H - TdR放射自显影）和腺体大小（组织平面测量法）来测定皮脂腺的反应。醋酸环丙孕酮无论局部还是全身给药，均能显著降低标记率和平面测量值。阻断5α - 还原酶的羧酸衍生物无效。这种新的动物模型是研究皮脂分泌抑制的一种敏感且合适的手段。
