Wirth H, Gloor M, Kimmel W
Arch Dermatol Res. 1980;268(3):277-81. doi: 10.1007/BF00404289.
The cell kinetics of the sebaceous gland of the hamster ear were analysed in untreated animals, in animals treated with cyproterone acetate, and in animals treated with estradiol. Both active substances lead to a reduction in the size of the sebaceous gland (measurement with the integration plate), to a reduction of mitoses (colcemide method), to a reduction in the 3H-thymidine labelling index, to a prolongation of the S-phase (double labelling technique with 3H- and 14C-thymidine), and to a decrease in the number of cells labelled with 3H-thymidine which remain in contact with the basal lamina of the sebaceous gland 6 days after application of the isotope. The results indicate that, like cyproterone acetate, estradiol reduces the effect of androgens on cell kinetics in the sebaceous gland under the test conditions chosen, even if in an entirely different way.
对未处理的仓鼠耳部皮脂腺的细胞动力学进行了分析，也对用醋酸环丙孕酮处理的动物以及用雌二醇处理的动物进行了分析。这两种活性物质均导致皮脂腺大小减小（用积分板测量）、有丝分裂减少（秋水仙酰胺法）、3H-胸腺嘧啶核苷标记指数降低、S期延长（3H-和14C-胸腺嘧啶核苷双标记技术），以及在施用同位素6天后，与皮脂腺基底膜保持接触的3H-胸腺嘧啶核苷标记细胞数量减少。结果表明，在所选的试验条件下，与醋酸环丙孕酮一样，雌二醇也会降低雄激素对皮脂腺细胞动力学的影响，尽管方式完全不同。
