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来自莫雷尔氏裂榄(橄榄科)的细胞毒性剂:脱氧鬼臼毒素和一种新的木脂素,5'-去甲氧基脱氧鬼臼毒素。

Cytotoxic agents from Bursera morelensis (Burseraceae): deoxypodophyllotoxin and a new lignan, 5'-desmethoxydeoxypodophyllotoxin.

作者信息

Jolad S D, Wiedhopf R M, Cole J R

出版信息

J Pharm Sci. 1977 Jun;66(6):892-3. doi: 10.1002/jps.2600660647.

DOI:10.1002/jps.2600660647
PMID:559755
Abstract

The isolation and identification of deoxypodophyllotoxin and a new lignan, 5'-desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.

摘要

报道了从多蕊裂榄(橄榄科)干燥渗出物中分离和鉴定脱氧鬼臼毒素及一种新木脂素5'-去甲氧基脱氧鬼臼毒素。脱氧鬼臼毒素在KB和PS测试系统中显示出高活性;这种新木脂素虽然对KB测试系统具有高活性,但对PS测试系统仅表现出微弱活性。文中提出了这种新木脂素的结构,并将其命名为裂榄素。

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