Hoffmann J J, Wiedhopf R M, Cole J R
J Pharm Sci. 1977 Apr;66(4):586-7. doi: 10.1002/jps.2600660433.
The chloroform fraction of Polygala macradenia exhibited activity against the P-388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4'-demethyldeoxypodophyllotoxin (C21H20O7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting-point determinations; and preparation of a derivative.
长梗远志的氯仿提取物对P - 388淋巴细胞白血病和人鼻咽癌测试系统显示出活性。负责此活性的成分是一种木脂素，4'-去甲基脱氧鬼臼毒素（C21H20O7）。通过元素分析、核磁共振氢谱（PMR）、红外光谱（IR）、质谱分析和熔点测定以及衍生物的制备证实了其结构。
