Kurihara T, Tanaka M, Shioya K
Folia Psychiatr Neurol Jpn. 1984;38(4):481-7. doi: 10.1111/j.1440-1819.1984.tb00798.x.
By exposing the rat hemidiaphragm preparations to various low chloride solutions, it was demonstrated that myotonia can be induced when the extracellular chloride concentration was reduced below 82 mEq/L. Myotonia can be induced simply by reducing the extracellular chloride concentration without any significant reduction of RMP. The intracellular and extracellular chloride activity was measured by the liquid ion exchanger microelectrode. The control intracellular chloride activity was 10.8 mEq/L and that of myotonic specimen in a low chloride solution of 47 mEq/L was 4.4 mEq/L. Chloride conductance was closely related to the extracellular chloride concentration and myotonia was induced when gc1 was 38.3% of the control.
通过将大鼠半膈肌标本暴露于各种低氯溶液中，结果表明，当细胞外氯离子浓度降至82 mEq/L以下时可诱发肌强直。仅通过降低细胞外氯离子浓度就能诱发肌强直，而静息膜电位（RMP）无显著降低。采用液体离子交换微电极测量细胞内和细胞外氯离子活性。对照时细胞内氯离子活性为10.8 mEq/L，在47 mEq/L的低氯溶液中肌强直标本的细胞内氯离子活性为4.4 mEq/L。氯离子电导与细胞外氯离子浓度密切相关，当氯离子电导（gc1）为对照值的38.3%时可诱发肌强直。
