Teige J, Nordstoga K
Acta Vet Scand. 1977;18(2):210-20. doi: 10.1186/BF03548449.
An anaphylactic reaction was provoked in pigs by two intravenous injections of chicken egg albumin given approx. 2 weeks apart; some of the animals were in a state of vitamin E deficiency. The second injection of albumin was followed by vomiting, forced respiration, severe cyanosis and distinct edema in the stomach, larynx and gall bladder. These pathomorphological changes are in accordance with those regarded as typical for edema disease. Both the clinical symptoms and the pathomorphological alterations were most evident in animals with vitamin E supplementation, whereas vitamin E deficient animals showed a more moderate response. The anaphylactic reaction was not accompanied by evident changes resembling Mulberry heart disease, either in normal pigs or in vitamin E deficient animals.
通过给猪大约每隔2周静脉注射两次鸡卵白蛋白引发过敏反应；部分动物处于维生素E缺乏状态。第二次注射白蛋白后，猪出现呕吐、强迫呼吸、严重发绀以及胃、喉和胆囊明显水肿。这些病理形态学变化与水肿病的典型变化相符。临床症状和病理形态学改变在补充维生素E的动物中最为明显，而维生素E缺乏的动物反应则较为温和。无论是正常猪还是维生素E缺乏的动物，过敏反应均未伴有类似桑葚心病的明显变化。
