[精神药物对实验性神经症中防御性条件反射形成的影响]
[Influence of psychotropic substances on elaboration of a defensive conditioned reflex in experimental neurosis].
作者信息
Burov Iu V, Speranskaia N P
出版信息
Biull Eksp Biol Med. 1977 Jun;83(6):696-8.
PMID:560227
Abstract
Neurosis resulting in alteration of the motor-defense conditioned reflex development occurred in rats subjected to a long-term action of a negative-emotional factor--neighbour-rat's reaction to pain. Benactyzine, diazepam, chlordiazepoxide, and sodium hydroxybutyrate improved the formation of defense conditioned reflex during this form of neurosis. Trioxazin, trifluoperazine, and amphetamine produced no such effect. The proposed model of experimental neurosis can be used to reveal the tranquilizing activity of psychotropic drugs.
摘要
在遭受负面情绪因素——邻鼠对疼痛的反应长期作用的大鼠中，出现了导致运动防御性条件反射发育改变的神经症。苯那辛、地西泮、氯氮卓和羟基丁酸钠在这种神经症形式下改善了防御性条件反射的形成。三氧嗪、三氟拉嗪和苯丙胺则没有这种作用。所提出的实验性神经症模型可用于揭示精神药物的镇静活性。
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