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[犬类神经症建模及抗抑郁药疗效研究]

[Modeling neurosis in the dog and a study of the effects of antidepressants].

作者信息

Aĭrapetiants M G, Mekhedova A Ia, Kozlovskaia M M, Neznamov G G

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Nov-Dec;36(6):1131-8.

PMID:3564689
Abstract

Introduction in tests with positive (alimentary) reinforcement, of elements of uncertainty and of "collision" of motivations, and carrying out of a series of experiments on dogs under such conditions during 2-4 weeks, led to the development of heavy and stable neurotic states. They were characterized by disturbances of emotional-motivational sphere, suppression of conditioned activity, somatovegetative dysfunctions. Preparations of atypical antidepressants (emovit and new benzamine derivate) reduced neurotic manifestations. The rate of reduction depended on the spectrum of neuro-psychotropic activity and properties of pathological states in dogs.

摘要

在具有阳性(食物性)强化、不确定性因素和动机“冲突”的试验中引入这些因素,并在2至4周的时间里在这种条件下对狗进行一系列实验,导致了严重且稳定的神经症状态的发展。它们的特征是情绪-动机领域的紊乱、条件性活动的抑制、躯体-植物性功能障碍。非典型抗抑郁药(emovit和新型苯丙胺衍生物)制剂可减轻神经症表现。减轻的程度取决于狗的神经精神活性谱和病理状态的性质。

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