Azzopardi J G, Zayid I
J Clin Pathol. 1967 Sep;20(5):731-8. doi: 10.1136/jcp.20.5.731.
Continuous therapy with synthetic progestogen-oestrogen produces marked atrophy of endometrial glands and massive pseudodecidual stromal transformation. Cyclical therapy produces initially a ;frustrated secretory response' with precocious attempts at secretion in poorly developed glands. Pseudodecidua appears about the 20th day. With later cycles there is progressively greater gland atrophy while pseudodecidua is less marked. A possible inductive role of the glands on the stromal response to progestogens is postulated. The effect of different drugs and dosages is discussed. Decidual necrosis may occur with heavy doses. The Arias-Stella reaction, previously regarded as diagnostic of pregnancy, can be produced with ordinary doses of these drugs. Suppression of spiral arterioles is usual. Ballooning of venules is a frequent finding, possibly accounting for breakthrough bleeding. Red degeneration of myomata was present in three of seven hysterectomy specimens containing myomata.
合成孕激素 - 雌激素的持续治疗会导致子宫内膜腺体显著萎缩以及大量假蜕膜样间质转化。周期性治疗最初会产生“受挫的分泌反应”，即在发育不良的腺体中过早出现分泌尝试。假蜕膜大约在第20天出现。在随后的周期中，腺体萎缩逐渐加重，而假蜕膜则不那么明显。推测腺体对间质对孕激素反应可能具有诱导作用。讨论了不同药物和剂量的影响。大剂量使用时可能会发生蜕膜坏死。以前被认为是妊娠诊断依据的阿rias - Stella反应，使用这些药物的常规剂量即可产生。螺旋小动脉的抑制较为常见。小静脉扩张是常见现象，可能是突破性出血的原因。在7个含有肌瘤的子宫切除标本中，有3个出现了肌瘤红色变性。
