Kopun M, Propping P
Eur J Clin Pharmacol. 1977;11(5):337-44. doi: 10.1007/BF00566530.
The influence of genetic and environmental factors on the metabolism of a single oral dose of ethanol 1.2 ml per kg body weight was analysed in 19 identical and 21 fraternal healthy, adult, un-selected male twin pairs. The heritability values of the rates of absorption, degradation and elimination of ethanol were 0.57, 0.41 and 0.46 respectively. Environmental factors, such as daily alcohol intake and smoking, increased the rate of elimination of blood alcohol. Intrasubject variation in ethanol metabolism was studied by repeated tests in 11 male volunteers at intervals of at least 2 months, under the same conditions as in the twins; the coefficients of variation for parameters of metabolism was about 8%. The results demonstrate both genetic control of ethanol absorption, degradation and elimination and the appreciable influence of environmental factors. The almost total genetic control of ethanol metabolism postulated by Vesell et al. (1971) could not be confirmed.
在19对同卵和21对异卵健康成年男性双胞胎中，分析了基因和环境因素对每千克体重口服1.2毫升乙醇单次剂量代谢的影响。乙醇吸收、降解和消除速率的遗传度值分别为0.57、0.41和0.46。环境因素，如每日酒精摄入量和吸烟，会增加血液中酒精的消除速率。在与双胞胎相同的条件下，对11名男性志愿者每隔至少2个月进行重复测试，研究乙醇代谢的个体内变异；代谢参数的变异系数约为8%。结果表明，乙醇的吸收、降解和消除受基因控制，同时环境因素也有显著影响。Vesell等人（1971年）假设的乙醇代谢几乎完全受基因控制这一观点无法得到证实。
