Laroche C, Remy J M, Caquet R, Letellier P
Sem Hop. 1975 Oct 23;51(42):2515-9.
In a young girl, aged 17 years, there occurred, 9 months after starting treatment with isoniazid and rifampicin, clinical signs of rheumatoid arthritis with facial erythema of vespertilio type. The presence of L.E. cells and antinuclear antibodies with a high titer, the rapid disappearance of all the clinical signs on stopping isoniazid, and the transient exacerbation of the syndrome on giving a single dose of isoniazid, gave the diagnosis of systemic lupus erythematosus induced by isoniazid. 18 months after stopping the drug, the patient is apparently cured, but there persists in the serum antinuclear antibodies in low concentration (1/200). A study of acetylation of isoniazid in this patient and her 3 sisters, showed that they were all of the slow acetylating phenotype. The late prognosis of this disease and the physiopathological value of the slow acetyl phenotype are worth discussion.
一名17岁的年轻女孩在开始使用异烟肼和利福平治疗9个月后，出现了类风湿关节炎的临床症状，并伴有蝙蝠型面部红斑。发现有狼疮细胞和高滴度抗核抗体，停用异烟肼后所有临床症状迅速消失，而给予单剂量异烟肼后综合征短暂加重，从而诊断为异烟肼诱发的系统性红斑狼疮。停药18个月后，患者明显治愈，但血清中仍存在低浓度（1/200）的抗核抗体。对该患者及其3个姐妹进行的异烟肼乙酰化研究表明，她们均为慢乙酰化表型。该病的远期预后以及慢乙酰化表型的生理病理意义值得探讨。
