Hamperl H
Virchows Arch A Pathol Anat Histol. 1975 Dec 29;369(1):55-68. doi: 10.1007/BF00432461.
The lesion, known under several names, consists of an hyalinized sclerotic center containing abundant elastic and elastoid masses. These radiate into the periphery and enclose lobuli which reveal epithelial proliferation varying from simple hyperplasia with epithelial villi to the rather rare true papillomas. The hyaline and elastic masses in the central parts surround tubuli and correspond to a lesion known as obliterating mastitis (mastopathy) that may lead to total occlusion of the ducts. The entire process ends with a contracting scar that alters the lobuli stemming from the obliterated duct. These may atrophy, dilate, or respond with different forms of hyperplasia. Therefore the designation "radial scars (scarring) possibly with epithelial proliferation" is proposed. As is emphasized the condition may be associated with tubular carcinoma and may resemble pseudoinfiltration in sclerosing adenosis.
该病变有多个名称，由一个玻璃样硬化中心组成，中心含有丰富的弹性和类弹性物质。这些物质向周边呈放射状分布，并包围小叶，小叶显示出上皮增生，从伴有上皮绒毛的单纯增生到相当罕见的真性乳头状瘤不等。中央部分的玻璃样和弹性物质围绕小管，对应于一种称为闭塞性乳腺炎（乳腺病）的病变，这种病变可能导致导管完全闭塞。整个过程以收缩性瘢痕结束，该瘢痕改变了源自闭塞导管的小叶。这些小叶可能萎缩、扩张，或出现不同形式的增生反应。因此，建议使用“可能伴有上皮增生的放射状瘢痕（瘢痕形成）”这一名称。需要强调的是，这种情况可能与小管癌相关，并且可能类似于硬化性腺病中的假浸润。
