Egger H, Dressler W
Arch Gynecol. 1982;231(3):191-8. doi: 10.1007/BF02110118.
Breast duct obliteration and periductal elastosis were studied in 100 breast carcinomas with a maximum diameter of 20 mm or less. Seventy percent of all tumours and 90% of lobular and tubular carcinomas had obliterated ducts with radial scars at the centre of the lesion. Obesity, parity and diabetes mellitus had no apparent association with duct obliteration and periductal elastosis. The striking two peaks in age distribution suggest the presence of endocrine influences. Duct obliteration with periductal elastosis occurs where the breast shows most changes during development and involution making this the high risk zone for carcinogenesis.
对100例最大直径为20毫米或更小的乳腺癌进行了乳腺导管闭塞和导管周围弹性组织变性的研究。所有肿瘤的70%以及小叶癌和管状癌的90%在病变中心有闭塞导管并伴有放射状瘢痕。肥胖、产次和糖尿病与导管闭塞和导管周围弹性组织变性无明显关联。年龄分布中显著的两个高峰提示存在内分泌影响。导管闭塞伴导管周围弹性组织变性发生在乳腺在发育和退化过程中变化最大的部位，使其成为致癌的高风险区域。
