Mizerski J, Pryjma J, Ptak W
Arch Immunol Ther Exp (Warsz). 1977;25(3):297-302.
The ability of high and low antigen doses (SRBC) to recruit IgM memory cells has been compared in several strains of mice. In intact animals priming with low doses was more efficient than priming with high doses. If, however, mice of different strains were X-irradiated two days after priming and repopulated, regardless of whether syngeneic or allogeneic splenocytes were used, they fell into two categories--those in which more memory cells were found after low antigen priming and those in which the reverse was true (Swiss mice). Two possible explanations are offered to explain these interstrain differences--antibody mediated suppression, and generation of suppressor T cells. Our data favor the latter, and we assume that suppressor T cells appear at different intervals after priming in different strains of mice, and that these cells are radioresistant.
在几种品系的小鼠中，已对高剂量和低剂量抗原（绵羊红细胞）募集IgM记忆细胞的能力进行了比较。在未受损伤的动物中，低剂量致敏比高剂量致敏更有效。然而，如果在致敏两天后对不同品系的小鼠进行X射线照射并重新植入细胞，无论使用的是同基因还是异基因脾细胞，它们都可分为两类——低抗原致敏后发现更多记忆细胞的小鼠和情况相反的小鼠（瑞士小鼠）。针对这些品系间差异提供了两种可能的解释——抗体介导的抑制作用和抑制性T细胞的产生。我们的数据支持后者，并且我们假设抑制性T细胞在不同品系小鼠致敏后的不同时间间隔出现，并且这些细胞具有辐射抗性。
