Niles L P, Brown G M, Grota L J
Neuroendocrinology. 1977;23(1):14-22. doi: 10.1159/000122650.
The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or immunization did not alter resting Prl levels or the response to novelty stimulation. Exposure to short photoperiods flattened the diurnal Rrl rhythm seen in control rats kept in 12 h of light and 12 h of darkness daily. Pinealectomy slightly lowered Prl levels but did not affect the diurnal rhythm. Immunization caused a significant reduction in Prl levels, although the diurnal Prl rhythm persisted. These data suggest that Mel and/or NAS may be involved in the maintenance of basal Prl levels.
在大鼠中，通过致盲或暴露于短光照周期（每天1小时光照和23小时黑暗）诱导松果体刺激后，研究了松果体切除或针对褪黑素（Mel）和N - 乙酰血清素（NAS）的免疫对血浆催乳素（Prl）水平的影响。单独致盲或与松果体切除或免疫联合使用均未改变静息Prl水平或对新奇刺激的反应。暴露于短光照周期使每天处于12小时光照和12小时黑暗的对照大鼠中观察到的昼夜Prl节律变平。松果体切除使Prl水平略有降低，但不影响昼夜节律。免疫导致Prl水平显著降低，尽管昼夜Prl节律仍然存在。这些数据表明，Mel和/或NAS可能参与基础Prl水平的维持。
