Yu H S, Pang S F, Tang P L, Brown G M
Neuroendocrinology. 1981 May;32(5):262-5. doi: 10.1159/000123170.
To study the effect of pinealectomy (Px) on the rhythms of serum indoles, male rats were adapted to 12L:12D for 2 weeks after which half of them were Px. The animals were decapitated at 4-hour intervals 1 week after operation. Melatonin (Mel) and N-acetylserotonin (NAS) were extracted and quantified by RIA. The concentrations of serum Mel and NAS were significantly reduced after Px, suggesting that the pineal contributes a significant amount of these to the blood. However, circadian rhythms of them were not abolished by Px, indicating the existence of extrapineal sources at least one of which is capable of secreting Mel and NAS wih a diurnal rhythm. Retina is suspected to be an important source.
为研究松果体切除（Px）对血清吲哚节律的影响，雄性大鼠先在12小时光照：12小时黑暗条件下适应2周，之后其中一半接受Px手术。术后1周，每隔4小时将动物断头。通过放射免疫分析法提取并定量褪黑素（Mel）和N - 乙酰血清素（NAS）。Px术后血清Mel和NAS浓度显著降低，表明松果体对血液中这些物质的贡献很大。然而，Px并未消除它们的昼夜节律，这表明存在松果体外的来源，其中至少有一个能够以昼夜节律分泌Mel和NAS。视网膜被怀疑是一个重要来源。
