Vinogradova E I
Probl Endokrinol (Mosk). 1977 Jul-Aug;23(4):39-43.
The method of thin-layer chromatography was applied to the study of renal excretion of 6beta-hydroxycortisol in 56 healthy neonates whose mothers were sufferin from late toxemia and in 9 women with 39-40 weeks of gestation. The proportional of 6beta-hydroxycortisol in the sum total of cortisol metabolites excreted in neonates the first week after birth was found to constitute 23.5-26.9%. However, as in adults the predominant route of cortisol metabolism was formation of tetrahydroderivatives whose proportion in the sum total of the excreted compounds constituted 47.7-55.0%. A high 6beta-hydroxycortisol excretion level was noted at the end of pregnancy. Equal amounts of 6beta-hydroxycortisol were excreted in healthy neonates and in children whose mothers were suffering from late toxemia of pregnancy. 6beta-hydroxycortisol formation is the usual independent route of cortisol metabolism in neonates the first week after birth.
采用薄层色谱法研究了56例母亲患有晚期妊娠毒血症的健康新生儿以及9例妊娠39 - 40周妇女的6β-羟基皮质醇的肾脏排泄情况。结果发现，出生后第一周新生儿排泄的皮质醇代谢产物总量中，6β-羟基皮质醇的比例为23.5% - 26.9%。然而，与成年人一样，皮质醇代谢的主要途径是形成四氢衍生物，其在排泄化合物总量中的比例为47.7% - 55.0%。在妊娠末期观察到6β-羟基皮质醇的排泄水平较高。健康新生儿和母亲患有晚期妊娠毒血症的儿童排泄的6β-羟基皮质醇量相等。6β-羟基皮质醇的形成是出生后第一周新生儿皮质醇代谢通常的独立途径。
