纳洛酮诱发的痛觉过敏在对疼痛刺激的反应性方面呈现昼夜节律。
Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli.
作者信息
Frederickson R C, Burgis V, Edwards J D
出版信息
Science. 1977 Nov 18;198(4318):756-8. doi: 10.1126/science.561998.
PMID:561998
Abstract
A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of endogenous opioid peptides and may partly account for previous controversy over the direct action of naloxone in opiate-naive animals.
摘要
观察到小鼠对伤害性刺激的反应性以及内源性阿片肽的痛觉过敏活性存在昼夜节律，这可能部分解释了先前关于纳洛酮对未使用过阿片类药物动物直接作用的争议。
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