Brandes J M, Atad J, Zuckerman H
Biol Neonate. 1977;31(5-6):283-8. doi: 10.1159/000240976.
High level of maternal serum alkaline phosphatase (AP) (above 4 Bessey-Lowry units) was found to be indicative of meconium-stained amniotic fluid (AF). Simultaneous maternal serum AP and AF AP were measured in two groups: group A, the study group (78 cases), parturients with meconium-stained AF, and group B (29 cases), the control group, parturients with clear AF. A positive significant correlation was found between the level of AP in the AF and the level of AP in the parturient's serum, when meconium was present. It is our feeling that the high level of AP in the maternal serum is due to transfer of heat-labile AP from the meconium-stained AF, meconium being rich in AP. The mechanism has as yet to be elucidated.
研究发现，孕妇血清碱性磷酸酶（AP）水平较高（高于4贝西-洛瑞单位）表明羊水（AF）被胎粪污染。对两组孕妇同时测定母体血清AP和羊水AP：A组为研究组（78例），羊水被胎粪污染的产妇；B组为对照组（29例），羊水清澈的产妇。当存在胎粪时，羊水AP水平与产妇血清AP水平之间存在显著正相关。我们认为，母体血清中AP水平较高是由于胎粪污染的羊水中热不稳定AP的转移，胎粪富含AP。其机制尚待阐明。
