暴露于高浓度氧气下的鸡胚视网膜的脂质过氧化物水平。

Lipoperoxide level of the retina of chick embryo exposed to high concentration of oxygen.

作者信息

Yagi K, Matsuoka S, Ohkawa H, Ohishi N, Takeuchi Y K, Sakai H

出版信息

Clin Chim Acta. 1977 Oct 15;80(2):355-60. doi: 10.1016/0009-8981(77)90044-4.

Abstract

To approach the mechanism of degeneration of the retina in retinopathy of prematurity, a model experiment using chick embryo was carried out. Upon exposing chick embryo at various stages to a high concentration of oxygen at 2 atm pressure, lipoperoxide levels of both the blood and the retina were elevated. The change in lipoperoxide level of the liver was not significant, except for a slight increase at the 9th day of incubation. Upon exposing chick embryo of the 14th day to high concentration of oxygen at ambient pressure, lipoperoxide levels of both the blood and the retina were elevated at 6 h and 12 h of exposure, but significant change was not observed in the lipoperoxide level of the liver.

摘要

为了探究早产儿视网膜病变中视网膜变性的机制，进行了一项使用鸡胚的模型实验。在将不同发育阶段的鸡胚暴露于2个大气压的高浓度氧气中后，血液和视网膜中的脂质过氧化物水平均升高。肝脏中脂质过氧化物水平的变化不显著，仅在孵化第9天时略有增加。将第14天的鸡胚暴露于常压下的高浓度氧气中后，在暴露6小时和12小时时，血液和视网膜中的脂质过氧化物水平均升高，但肝脏中脂质过氧化物水平未观察到显著变化。