Westenberg I S, Paige G, Golub B, Weinberger N M
Electroencephalogr Clin Neurophysiol. 1976 Apr;40(4):337-55. doi: 10.1016/0013-4694(76)90186-3.
In experiment 1 cats were exposed to sets of clicks (trials) with 1 min inter-trial-intervals to determine if the effects of repetitive stimulation on potentials evoked in the auditory cortex would be cumulative despite discrete-trial stimulation. Evoked potentials were averaged to give one average evoked potential (AEP) for each trial for each electrode; there were four cortical electrodes per subject. To test for dishabituation pawshocks were given between trials 60 and 61. Subjects were paralyzed to insure stimulus constancy. The latency and peak-to-peak amplitude of each component of each AEP was measured; significant amplitude decremented; and decrements were more frequent in components with latencies greater than 15 msec. A few amplitude increments and latency changes were also observed...
在实验1中，猫被暴露于一系列滴答声（试验），试验间隔为1分钟，以确定尽管是离散试验刺激，但重复刺激对听觉皮层诱发电位的影响是否会累积。诱发电位被平均，以便为每个电极的每次试验给出一个平均诱发电位（AEP）；每个受试者有四个皮层电极。为了测试去习惯化，在第60次和第61次试验之间给予爪子电击。使受试者瘫痪以确保刺激的恒定性。测量每个AEP每个成分的潜伏期和峰峰值幅度；显著的幅度减小；并且在潜伏期大于15毫秒的成分中，减小更为频繁。还观察到一些幅度增加和潜伏期变化……
