Hefco V, Rotinberg P
J Physiol (Paris). 1977 Oct;73(5):675-83.
The experiments of mechanical isolation of medial hypothalamus from the lateral hypothalamus and the preoptic anterior hypothalamic (POAH) region in rats showed that: 1. The interruption of neural connections between POAH area and medial hypothalamus do not prevent the decrease of food intake which normally occur in a hot environment. 2. At 33 degrees C, hyperphagic rats gained more weight than sham-operated ones. 3. At 4 degrees C, rats made hyperphagic by hypothalamic isolation do not ajust their food intake for a long period and do not gain weight. 4. The excitatory pathways of the feeding center from the POAH area do not penetrate directly into the lateral hypothalamus, but rather into the medial retrochiasmatic area. 5. The temperature influences the diurnal pattern of feeding only in rats with intact or unilateral neural connections of the hypothalamic structures 6. It seems that the thermostatic mechanism, which is a potent regulator of feeding, is closely associated with the central control of thyrotropin release, and that the hypothalamic structures may be considered only as a necessary link in the nervous mechanism involved in feeding control.
对大鼠进行内侧下丘脑与外侧下丘脑以及视前区-下丘脑前部（POAH）区域的机械分离实验，结果表明：1. POAH区域与内侧下丘脑之间神经连接的中断并不会阻止在炎热环境中正常发生的食物摄入量减少。2. 在33摄氏度时，食欲亢进的大鼠比假手术组大鼠体重增加更多。3. 在4摄氏度时，通过下丘脑分离导致食欲亢进的大鼠在很长一段时间内不会调整其食物摄入量，体重也不会增加。4. 来自POAH区域的摄食中枢兴奋通路并非直接进入外侧下丘脑，而是进入视交叉后内侧区域。5. 温度仅在具有完整或单侧下丘脑结构神经连接的大鼠中影响每日摄食模式。6. 恒温机制似乎是摄食的有力调节因子，它与促甲状腺激素释放的中枢控制密切相关，并且下丘脑结构可能仅被视为参与摄食控制的神经机制中的一个必要环节。
