Shoustek Z, Blazhek M
Kardiologiia. 1977 Sep;17(9):89-93.
Hypertrophy of the heart of unrecognized origin is a frequent finding on autopsy and in that case is related to the so-called nonobstructive idiopathic cardiomyopathy. Abnormality of the heart muscle is considered its main symptom. According to the authors, involvement of the ascending aorta and not the myocardium is the basic pathologic process. This "aortic dystrophy" is characterized by diffuse ectasia of the ascending aorta and typical microscopic histological signs. Hypertrophy of the left heart is evidently overexertion hypertrophy resulting from the increased volume of the ascending aorta and the diminished elasticity of the aortic wall after the ventricular systole and the consequent greater demand on the work of the left ventricle than in normal conditions. "Idiopathic" hypertrophy of the heart with dystrophy of the aorta is hereditary, it may involve the skeleton also, and may be manifested in relatives.
病因不明的心脏肥大在尸检中经常发现，这种情况下与所谓的非梗阻性特发性心肌病有关。心肌异常被认为是其主要症状。据作者称，升主动脉而非心肌受累是基本病理过程。这种“主动脉营养不良”的特征是升主动脉弥漫性扩张和典型的微观组织学征象。左心肥大显然是由于升主动脉容量增加以及心室收缩后主动脉壁弹性降低，导致左心室工作负荷比正常情况更大而引起的过度劳累性肥大。伴有主动脉营养不良的“特发性”心脏肥大具有遗传性，也可能累及骨骼，并可能在亲属中表现出来。
