阿普利西诺psin：一种从海洋海绵Verongia spengelii中提取的抗肿瘤色氨酸衍生物。
Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii.
作者信息
Hollenbeak K H, Schmitz F J
出版信息
Lloydia. 1977 Sep-Oct;40(5):479-81.
PMID:562965
Abstract
Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L1210 cell cultures.
摘要
对海洋海绵Verongia spengelii的水醇提取物进行生物测定导向的分级分离以寻找肿瘤抑制因子，从而分离出了阿朴色胺，这是一种最近从另一种海绵Thorecta aplysinopsis中报道的新型色氨酸衍生物。阿朴色胺对KB、P388和L1210细胞培养物显示出细胞毒性。
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